PIM kinases, or proviral integration site for Moloney murine leukemia virus kinases, are a group of serine/threonine protein kinases that play a role in regulating cell survival, proliferation, and differentiation. These kinases have been implicated in various human cancers, including lymphoma, leukemia, and solid tumors. Research on PIM kinases focuses on understanding their molecular mechanisms, identifying their downstream targets, and developing targeted therapies to inhibit their activity in cancer cells. These studies aim to provide insights into the potential therapeutic use of PIM kinase inhibitors in the treatment of cancer.